Apr 17, 2017
In this episode Dr Nirala Jacobi speaks with Dr Bradley Bush
about the fascinating and complex world of neurotransmitters.
Dr Bush received his Naturopathic Doctorate degree from the
National College of Naturopathic Medicine. He is co-owner and
clinic director of Natural Medicine of
Stillwater and its online consumer direct website for
The Bush practice focuses on fatigue, insomnia, GI disorders,
mood disorders, and lyme disease. Dr Bush has over 16 years of
industry experience. He is the owner of Natural Health Insights,
providing consulting services to the naturopathic products and
laboratory testing industry.
Dr Bush speaks nationally and regularly publishes on the topics
of neuroimmunology, brain-gut connections, neuroendocrinology, and
lyme disease. Dr Bush sits on two non profit boards, The
Naturopathic Education and
Research Consortium, and Compass Centre for
In this episode topics discussed include:
- Who are the major players in the enteric nervous system for
- Does low serotonin in the gut mean low serotonin in the
- The sympathetic-parasympathetic rhythm, and how important this
is in calibrating the smooth muscle movement in the
- Underlying factors to sympathetic dominance in a person, such
as chronic infection, dysbiosis, and/or inflammation.
- The complex presentations of sympathetic overdrive, ranging
from anxiety and insomnia, to exhaustion, and why this is.
- Why increased norepinephrine in conjunction with normal or low
epinephrine is a worse situation than just high epinephrine, due to
the lack of counter balance for inflammation and an upregulated
- Repercussions of high epinephrine in conjunction with low
- The multiple actions of cortisol, epinephrine, and
norepinephrine in the body and their roles in acute and chronic
- Urinary transmitter analysis, stability, and recommended
- Nutrients used to support synthesis of the various
- L-dopa v.s. tyrosine use, and the various benefits of
- Clinical indications for L-dopa use.
- How depleted catecholamines can be related to low secretory
- Genetic mutations (MTHFR) and how this relates to
- Does serum C-reactive protein (CRP) directly correlate to SIBO
- Myeloperoxidase measurement as a marker of neutrophil activity,
and how it can be a useful monitoring tool for irritable bowel
syndrome (IBS) and irritable bowel disease (IBD) patients.
- How does inflammation turn down the synthesis of serotonin and
- How the indoleamine 2,3-dioxygenase enzyme (IDO) conducts “The
Tryptophan Steal” as an outcome of chronic inflammation, and the
implications of this.
- What solutions are there to address the tryptophan steal?
- The benefit of using supplemental 5-HTP over tryptophan in
light of chronic inflammation and impacted adrenal health.
- Doses, dose timing, and length of time to use 5-HTP.
- SIBO as a common underlying factor for the inflammatory state
that can drive neurotransmitter dysfunction.
- What is the role of glutamate?
- Glutamate versus glutamine, and how is this relevant to
- How is glutamate measured, what do high levels indicate, and
how does it impact the nervous system?
- Glutathione as the biggest byproduct of L-glutamine
- Powder V.S. tablet for L-glutamine use, and the dose
- What is urinary neurotransmitter testing reflecting?
- The blood-brain barrier, and how the brain is not a closed
- MTHFR and COMT genetic testing as indicated by low monoamine
neurotransmitters and high catecholamines on urinary
- What to do with patients on medications being used to
conventionally regulate neurotransmitters?
- Tactics of improving neurotransmitter markers prior to SIBO
treatment in order to offset the flaring of the symptoms during die