Oct 9, 2017
In this episode Dr Nirala Jacobi is in conversation with Dr
Christopher Shade. Dr Shade is the CEO and founder of Quicksilver
Scientific, a lab that specialises in the environmental,
biological, and analytical chemistry of mercury and all of its
forms, and its interaction with sulphur compounds, particularly
glutathione, and its enzyme systems.
Dr Jacobi met Dr Shade at the Bioceuticals Research Symposium in
Sydney, 2017, and was riveted by his presentation on
Topics discussed in this episode include:
- The liver, gallbladder, and GI connection, and how to align
them so as to clear gastrointestinal issues.
- How failure to move bile is at the heart of detox reactions
- Bile as a detergent in the small intestine and how bile can be
a core issue in SIBO.
- Bile acid destruction and fat malabsorption in SIBO.
- Emunctories and what this means.
- Drainage areas and how the extracellular space is cleared.
- Metal binder for the GI tract that is far better than chlorella
- IMD microsilica
- Toxin conjugates and their interaction with bile salts.
- Phosphatidylcholine (PC), its requirement to fluidise the bile,
and choline’s relationship to cholestasis.
- Lipopolysaccharide (LPS) endotoxins from leaky gut (from SIBO)
creating inflammation in the hepatocytes and the flow on effects
- Phase 3 detoxification - The role of bile flow in lessening
detoxification reactions through lowering toxic conjugate buildup
in the blood, and instead moving them through the proper
- The importance of addressing emunctories in treating skin
- How LPS impairs phase 3 in the liver.
- Neurological consequences of leaky gut, SIBO, and of a
- Neuroinflammation, LPS, and a leaky blood brain barrier.
- Movement of metals into the urinary flow and how it has nothing
to do with glomerular filtration rate (GFR), even though this is
what is commonly measured for kidney function.
- Organic anion transport peptide’s (OATP) role in bringing toxic
conjugates from the blood into the proximal tubular epithelial
cells in the kidneys, then the movement of the toxic conjugates
into the urinary flow through the MRP2 transporter.
- MRP2 and how LPS and metals can block it.
- How the same things that shut down liver transport of toxic
conjugates, can also shut down kidney transport.
- Does LPS affect GFR?
- Active transport of toxins happens in the proximal tubules of
the kidney, not in the glomerulus.
- Kidney disfunction and how SIBO can be related to proximal
tubule damage in the kidney due to the build up of LPS.
- Proximal tubule function test available - Mercury
Tri-Test from Quicksilver Scientific.
- Genetic Single Nuclear Polymorphisms (SNPs) and how the
transport protein SNPs are commercially uncharted as yet.
- How inflammation blocks detoxification.
- Chronic infections turning down detoxification.
- Ways to address phase 3 detox.
- Address under-functioning gallbladder with PC, for
- Address leaky gut so that toxins dumped into small intestine do
- Strong bitters before meals.
- Take multi-toxin binder (30 minutes after taking bitters) -
this is important to do 30 minutes after bitters.
- Dr Nirala Jacobi uses Toxaprevent, but not in SIBO-C
- Dr Shade uses:
Metal binder eg. IMD (much stronger than chlorella),
- Acacia gum
- For leaky gut
- Low FODMAPS
- Bifidogenic prebiotic
- Powdered Aloe
- Marshmallow root
- Slippery elm
- Is there a test to assess phase 3 detox function?
- NRF2 upregulators and their role in cellular detoxification, to
be implemented AFTER liver and kidney detoxification is
- The importance of NRF2 and the effects it has on the body.
- Dr Shade’s universal binder -
- How to access Dr Shade’s products.
- Dr Shade’s recipe for a self made toxin binder.
- The importance of Myrrh in the bitters
- The bitter detoxifier in ayurvedic medicine, qi and blood mover
in chinese and ayurvedic medicine, and strong antimicrobial.
- Cautions with long term myrrh supplementation.
- Other herbals bitters to include:
- Solidago (Golden Rod)
- Dr Jacobi’s bitters blend
- Oregon grape
- Baical Skullcap
- Bitters as opening up the bile, tonifying the kidneys, and
restoring ileocecal valve function.
- What is the function of bitter receptors on the ovaries?
- If SIBO clients are Hydrogen Sulfide dominant note that the
bacteria involved here are bile loving, so any cholagogues will
exacerbate the SIBO issue.
- Does charcoal absorb all of your minerals?
- Using charcoal as the primary binder - amounts to take and
rationale for diversifying binder portfolio.
- Is mercury stored in biofilm?
- Is it advised to disrupt biofilm, or is it dangerous to do
- EDTA as a biofilm breaker.
- Plaques in the vascular system are actually biofilms.
- What mercury testing is offered at Quicksilver Scientific?
- Is it worth testing for mercury toxicity?
- When is it good to test people for mercury toxicity?
- How healing the GI tract can heal the kidneys.
- What is the evil of amalgam fillings?
- Why people with amalgams often have to urinate a lot at
- The body has it’s own inbuilt chelating system - glutathione,
glutathione-s-transferase, and the transport proteins.
- What are the myths of chelation agents?
- Is lipoic acid a chelator, or is it upregulating the body’s
natural chelation system?
- The importance of lining up all the drainage, and lining up all
the phases of detoxification.
- Hydrotherapy for the lymphatics.
- The issues in Australia with lead and aluminum - Dr Shade’s
recommendation on how to test these areas:
- Excess copper in the presence of low zinc can become
synergistically toxic with all toxic metals.
- Whole blood vs intracellular for testing?
- How do you measure intracellular stores?
- Residence time in the blood of different metals.
- Dr Shade’s last pearls of wisdom - start with drainage, then
move to mobilisation after levels come down first with good