Nov 23, 2017
In today’s episode, Dr Nirala Jacobi is in conversation with
Dr Carrie Jones. Dr
Jones is a Naturopathic Doctor and hormone specialist from
Portland. She has completed a two-year residency in advanced
women’s health, gynaecology and hormones, and has also completed
her Masters of Public Health at the Grand Canyon University. Dr Jones
has been the medical director of two large integrative medical
clinics in Portland and is currently the medical director of
Precision Analytical, a
laboratory that offers the DUTCH
Profile. She writes for multiple health websites and is
featured in a range of health podcasts.
Topics discussed include
- Hormones and their relationship to functional digestive
- Digestive flares before a woman’s period and why this can
- How gut inflammation can affect hormones - for example by
raising cortisol, raising estrogen, raising 5 alpha reductase,
lowering dehydroepiandrosterone sulfate (DHEA-S), affecting the
absorption of nutrients that comprise hormones.
- How lipopolysaccharides (LPS) and endotoxemia can impair and
congest phase 1 and 2 liver detoxification pathways.
- Nutritional cofactors required to support smooth
Catechol-O-methyltransferase (COMT) functioning, especially in
light of COMT single-nucleotide polymorphisms (SNPs).
- Symptoms of estrogen dominance in men and women.
- Hormone patterns related to a dysfunctional gut
- The estrobolome and how it can dictate how much
beta-glucuronidase is produced, as well as how much
dehydroepiandrosterone (DHEA) is released from the body.
- All about estrogen metabolism, the different metabolites that
are produced, which ones are beneficial, and the liver pathways
used for processing.
- Which estrogen metabolising pathways have associated cancer
- The role of beta-glucuronidase in disrupting estrogen
- High toxic load patients and how hormone disruptors affect CYP
enzymes and estrogen receptors.
- How can a patient show symptoms of estrogen dominance and yet
their hormonal profiles be ok?
- Hint: If proliferative estrogen metabolising pathways
- When to intervene for hormonal balance when client presents
with gastrointestinal issues?
- In light of high levels of beta-glucuronidase.
- How to test for beta-glucuronidase - fecal.
- What can we do about estrogen dominance?
- Support for Phase 1
- Diindolylmethane (DIM) for clients favouring unhealthy 4-OH E1
or 16a-OH E1 pathways.
- Dietary adjustment to include Indole-3-carbinol (I3C)
- Broccoli sprout powder for sulforaphane (to activate quinone
- Helps reverse the effects of going down unhealthy 4-OH E1
- Glutathione support with N-acetylcysteine (NAC), and liposomal
- Support for Phase 2 (COMT support)
- Methylated B Vitamins
- S-Adenosyl-L-Methionine (SAMe)
- Gut treatment
- Calcium D-glucarate to help lower beta-glucuronidase
- Fibrous foods to bind free floating estrogen.
- Note: Broccoli and fibrous products not recommended in phase 1
of SIBO treatment.
- When to use binders in detoxification treatment.
- Why can people with bloating potentially be progesterone
- Progesterone cream in second half of the cycle versus vitex
supplementation - what age groups are appropriate to each?
- DUTCH testing - what is
the difference between all the testing available?
- Saliva tests - free hormones.
- Blood tests - hormones are bound to sex hormone binding
globulins or other carrier proteins.
- DUTCH test - free hormones and metabolites.
- Cortisol and cortisone - how to assess beyond an adrenal stress
index, the difference between both forms, and why the body may have
a pattern of inactivating cortisol into cortisone.
- How to balance cortisol to cortisone ratio?
- The role of licorice (Glycyrrhiza glabra)
- Flatlining cortisol and its role as a marker for chronic
infection, its association with an increased risk for cancer, and
increased risk for autoimmune issues.
- The cortisol awakening response and how it works with the
thymus gland to destroy autoimmune antibodies.
- The link between chronic infections and low cortisol, and how
- All about DHEA and DHEA-S
- Counters stress
- Energy, bone health, neurotransmitter balance, sex drive,
- 7-keto DHEA - what is this?
- Supporting DHEA via adrenal support.
- When and when not to test hormone levels.
- Endometriosis and digestive disturbance due to adhesions,
inflammation, and excess estrogen.
- New developments in the hormonal testing field.
- IBS symptoms around the period and why this may be.
- The importance of structural alignment for uterine and
- Therapy to address structural alignment - visceral
manipulation, pelvic massages, and bodywork.
- Helpful for estrogen dominance
- Raises SHBG (note that flaxseeds preferentially bind
testosterone - so care in women who are struggling with
- The role of fermented soy for hormonal balance in
- Is soy estrogenic, or does it downregulate the proliferative
- Dr Carrie Jones’ 2018 hormone education plans for practitioners